Which nutrient-related management strategy is often ineffective in treating high serum uric acid levels?

The choice of increasing dietary purines as a management strategy for high serum uric acid levels is often ineffective because purines are compounds found in many foods that are broken down into uric acid in the body. When dietary purine intake is increased, it can lead to elevated uric acid levels, which is the opposite of the desired effect in managing conditions such as gout or hyperuricemia. Instead, it's beneficial to minimize purine-rich foods—such as certain meats, fish, and some legumes—to help lower uric acid production and maintain healthier serum levels.

In contrast, increasing fluid intake is generally encouraged as it aids in the excretion of uric acid through urine. Limiting alcohol intake is also considered a prudent approach since alcohol can raise uric acid levels and inhibit its excretion. Decreasing fluid intake is counterintuitive because dehydration can result in higher concentration of uric acid in the blood, worsening the situation. Therefore, while all the other options are grounded in effective management strategies, increasing dietary purines directly contradicts the goals of treatment in managing high serum uric acid.