Which nutrient is most impaired in individuals with cystic fibrosis?

Individuals with cystic fibrosis primarily experience impaired digestion and absorption of fats due to the thick, sticky mucus that obstructs the pancreatic ducts. This obstruction prevents enzymes from reaching the intestines, where they are needed for proper fat digestion, leading to malabsorption. Consequently, fats in the diet become poorly absorbed, which can result in a deficiency of essential fatty acids and fat-soluble vitamins (A, D, E, K).

While protein, disaccharides, and electrolytes can also be affected due to the overall malabsorption issues associated with cystic fibrosis, the most pronounced and direct impact is on fat absorption. This is why fat is specifically highlighted as the nutrient most impaired in individuals with this condition.